EFLM Biological Varation Database : BIVAC Minimum Data Set for a-2 macroglobulin level EFLM Biological Variation

a-2 macroglobulin level

Reference

Statland BE, Winkel P and Killingsworth LM, 1976, Clin Chem, 22, 1635-8 , Factors Contributing to Intra-Individual Variation of Serum Constituents: 6. Physiological Day-to-Day Variation in Concentrations of 10 Specific Proteins in Sera of Healthy Subjects

Scoring

Total Score

C_8,10,12,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	A
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	C
11. ANOVA	A
12. CI	C
13. No of Results	C
14. Concentrations	B
15. Total Score	C_8,10,12,13
Comment

Item Details

Parameter	Score
Matrix	Serum
Measurand	a-2 macroglobulin level
Unit	g / L
Overall Analytical Principle Method	Unknown
Number of Subjects	14
Number of Subjects included in BV estimation	14
Ethinicity	Caucasian
Age Mean / Median
Age Min	25.0
Age Max	40.0
Age SD
Number of Males	8
Number of Females	6
State of Well Being	Healthy (excl pregnant)
Study Duration Length	6
Study Duration Units	Day
Sampling Intervals, e.g. X sample(s) per Interval Unit	1
Interval Units	Day
Sampling Times	Start Time: End Time:
Number of Samples	6
Average Number of Samples Used for BV Estimation	6.0
Average Number of Replicates	1.0
Estimates of CVi	3.1
Calculated Confidence Intervals of CVi	Lower: 0.00, Upper: 4.28
Estimates of CVg	16.6
Calculated Confidence Intervals of CVg	Lower: 12.10, Upper: 26.26
Analytical CV	2.9
Calculated Confidence Intervals of Analytical CV	Lower: 1.96, Upper: 5.56
Measurand Mean
Measurand Min
Measurand Max
Measurand SD

Coding

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