Nishiyama K, Tsutamoto T, Kawahara C et al, 2011, Circ J, 75, 1897-904 , Relationship Between Biological Variation in B-Type Natriuretic Peptide and Plasma Renin Concentration in Stable Outpatients With Dilated Cardiomyopathy


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C7,8,10,13

Item Details

Parameter Score
Matrix Plasma
Measurand Aldosterone
Unit pg / mL
Overall Analytical Principle Method Unknown
Number of Subjects 115
Number of Subjects included in BV estimation 115
Ethinicity Unknown
Age Mean / Median 60.7
Age Min 51.0
Age Max 70.4
Age SD
Number of Males 107
Number of Females 8
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length 2
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Month
Sampling Times Start Time: 13:00
End Time: 16:00
Number of Samples 2
Average Number of Samples Used for BV Estimation 2.0
Average Number of Replicates 1.0
Estimates of CVi 19.0
Calculated Confidence Intervals of CVi Lower: 16.45, Upper: 22.10
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: 14.40, Upper:
Analytical CV 6.2
Calculated Confidence Intervals of Analytical CV Lower: 4.82, Upper: 8.70
Measurand Mean 82.5
Measurand Min 37.9
Measurand Max 127.1
Measurand SD