Thyagarajan B, Howard AG, Durazo-Arvizu R, Eckfeldt JH, Gellman MD, Kim RS, Liu K, Mendez AJ, Penedo FJ, Talavera GA, Youngblood ME, Zhao L and Sotres-Alvarez D, 2016, Clin Chim Acta, 463, 129-137 , Analytical and biological variability in biomarker measurement in the Hispanic Community Health Study/Study of Latinos


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C7,8,10,12,13

Item Details

Parameter Score
Matrix Whole Blood EDTA
Measurand Neutrophils
Unit 10(9) / L
Overall Analytical Principle Method Flow cytometry - Laser
Number of Subjects 329
Number of Subjects included in BV estimation 329
Ethinicity Unknown
Age Mean / Median
Age Min 18.0
Age Max 74.0
Age SD
Number of Males 329
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 36
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 2
Average Number of Samples Used for BV Estimation 2.0
Average Number of Replicates 1.0
Estimates of CVi
Calculated Confidence Intervals of CVi Lower: , Upper:
Estimates of CVg 42.37
Calculated Confidence Intervals of CVg Lower: 0.00, Upper: 0.00
Analytical CV 2.7
Calculated Confidence Intervals of Analytical CV Lower: 2.31, Upper: 3.26
Measurand Mean 3.5
Measurand Min
Measurand Max
Measurand SD