Hansen AM, Garde AH, Skovgaard LT and Chistensen JM, 2001, Clin Chim Acta, 309, 25-35 , Seasonal and biological variation of urinary epinephrine, norepinephrine, and cortisol in healthy women


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C7,8,10,13
Comment Pre-menopausal. Select CVi in a year.

Item Details

Parameter Score
Matrix Urine
Measurand Cortisol
Unit micromol / mmol creatinine
Overall Analytical Principle Method Immunoassay; RIA
Number of Subjects 12
Number of Subjects included in BV estimation 11
Ethinicity Unknown
Age Mean / Median 35.0
Age Min 26.0
Age Max 44.0
Age SD
Number of Males
Number of Females 12
State of Well Being
Healthy (excl pregnant)
Study Duration Length 12
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time: 15:00
End Time: 18:00
Number of Samples 90
Average Number of Samples Used for BV Estimation
Average Number of Replicates 1.0
Estimates of CVi 59.0
Calculated Confidence Intervals of CVi Lower: 56.26, Upper: 61.94
Estimates of CVg 26.0
Calculated Confidence Intervals of CVg Lower: 17.85, Upper: 45.01
Analytical CV 15.7
Calculated Confidence Intervals of Analytical CV Lower: 13.78, Upper: 18.24
Measurand Mean 10.6
Measurand Min 0.65
Measurand Max 38.3
Measurand SD