Dittadi R, Damiani AF and Olcese C, 2018, Clin Chem Lab Med, 55(12), e285-e287 , Evaluation of serum cortisol biological variation in the evening withdrawal


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score C7

Item Details

Parameter Score
Matrix Serum
Measurand Cortisol
Unit nmol / L
Overall Analytical Principle Method Immunoassay; RIA
Number of Subjects 18
Number of Subjects included in BV estimation 18
Ethinicity Unknown
Age Mean / Median
Age Min 15.0
Age Max 63.0
Age SD
Number of Males 7
Number of Females 11
State of Well Being
Healthy (excl pregnant)
Study Duration Length 4
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time: 20:00
End Time: 20:00
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 1.0
Estimates of CVi 30.9
Calculated Confidence Intervals of CVi Lower: 23.86, Upper: 38.69
Estimates of CVg 31.3
Calculated Confidence Intervals of CVg Lower: 20.72, Upper: 49.49
Analytical CV 9.7
Calculated Confidence Intervals of Analytical CV Lower: 6.41, Upper: 19.74
Measurand Mean 86.9
Measurand Min 61.9
Measurand Max 161.1
Measurand SD