Thyagarajan B, Howard AG, Durazo-Arvizu R, Eckfeldt JH, Gellman MD, Kim RS, Liu K, Mendez AJ, Penedo FJ, Talavera GA, Youngblood ME, Zhao L and Sotres-Alvarez D, 2016, Clin Chim Acta, 463, 129-137 , Analytical and biological variability in biomarker measurement in the Hispanic Community Health Study/Study of Latinos


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C7,8,10,13

Item Details

Parameter Score
Matrix Whole Blood EDTA
Measurand Erythrocytes
Unit 10(12) / L
Overall Analytical Principle Method Flow cytometry - Laser
Number of Subjects 30
Number of Subjects included in BV estimation 30
Ethinicity Unknown
Age Mean / Median
Age Min 45.0
Age Max 74.0
Age SD
Number of Males
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 2
Average Number of Samples Used for BV Estimation 2.0
Average Number of Replicates 1.0
Estimates of CVi 2.3
Calculated Confidence Intervals of CVi Lower: 1.39, Upper: 3.17
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: 0.00, Upper:
Analytical CV 0.9
Calculated Confidence Intervals of Analytical CV Lower: 0.58, Upper: 1.98
Measurand Mean 4.7
Measurand Min
Measurand Max
Measurand SD