Procollagen type I N-terminal propeptide (PINP)


Alvarez L, Ricós C, Peris P, Guañabens N, Monegal A,Pons F and Ballesta AM, 2000, Bone, 26, 571-6 , Components of biological variation of biochemical markers of bone tumor in Paget’s bone disease


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI C
13. No of Results A
14. Concentrations A
15. Total Score C8,10,12

Item Details

Parameter Score
Matrix Serum
Measurand Procollagen type I N-terminal propeptide (PINP)
Unit ng / mL
Overall Analytical Principle Method Immunoassay; RIA
Number of Subjects 15
Number of Subjects included in BV estimation 15
Ethinicity Unknown
Age Mean / Median 40.0
Age Min 28.0
Age Max 49.0
Age SD 6.2
Number of Males
Number of Females 15
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Year
Sampling Intervals, e.g. X sample(s) per Interval Unit 3
Interval Units Month
Sampling Times Start Time: 8:00
End Time: 10:00
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 2.0
Estimates of CVi 10.0
Calculated Confidence Intervals of CVi Lower: 7.63, Upper: 13.23
Estimates of CVg 41.6
Calculated Confidence Intervals of CVg Lower: 30.49, Upper: 64.72
Analytical CV 7.4
Calculated Confidence Intervals of Analytical CV Lower: 6.28, Upper: 9.01
Measurand Mean 176.5
Measurand Min
Measurand Max
Measurand SD