EFLM Biological Varation Database : BIVAC Minimum Data Set for Pyridinoline level EFLM Biological Variation

Pyridinoline level

Reference

Beck Jensen et al. , 1997, Scand J Clin Lab Invest, 57, 351-60 , A single measurement of biochemical markers of bone turnover has limited utility in the individual person.

Originally from this reference: Scand J Clin Lab Invest, Beck Jensen et al. , 1997

ID: 0005

Scoring

Total Score

C_8,10,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	B
6. Replicate Analysis	A
7. Steady State	A
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	C
11. ANOVA	B
12. CI	A
13. No of Results	C
14. Concentrations	B
15. Total Score	C_8,10,13
Comment

Item Details

Parameter	Score
Matrix	Morning urine
Measurand	Pyridinoline level
Unit	nmol / mmol creatinine
Overall Analytical Principle Method	Chromatography; HPLC
Number of Subjects	30
Number of Subjects included in BV estimation	30
Ethinicity	Unknown
Age Mean / Median
Age Min	24.0
Age Max	62.0
Age SD
Number of Males
Number of Females	30
State of Well Being	Healthy (excl pregnant)
Study Duration Length	5
Study Duration Units	Week
Sampling Intervals, e.g. X sample(s) per Interval Unit	1
Interval Units	Week
Sampling Times	Start Time: End Time:
Number of Samples	5
Average Number of Samples Used for BV Estimation	5.0
Average Number of Replicates	2.0
Estimates of CVi	12.2
Calculated Confidence Intervals of CVi	Lower: 9.66, Upper: 14.97
Estimates of CVg	22.6
Calculated Confidence Intervals of CVg	Lower: 17.56, Upper: 30.82
Analytical CV	13.28
Calculated Confidence Intervals of Analytical CV	Lower: 11.93, Upper: 14.97
Measurand Mean
Measurand Min
Measurand Max
Measurand SD

Coding

Parameter	Score
Healthy Population	true
Adult Population	true
Weekly Samplings	true
Reviewed	true
Published	true
Gender for Meta-Analysis	Females
Snomed CT
NPU
LOINC
Comment

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