Panteghini M and Pagani F, 1995, Scand J Clin Lab Invest, 55, 609-16 , Biological variation in bone-derived biochemical markers in serum


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State C
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C7,8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Osteocalcin
Unit ug / L
Overall Analytical Principle Method Chemiluminescence
Number of Subjects 5
Number of Subjects included in BV estimation 5
Ethinicity Caucasian
Age Mean / Median
Age Min 25.0
Age Max 50.0
Age SD
Number of Males
Number of Females 5
State of Well Being
Healthy (excl pregnant)
Study Duration Length 4
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:00
End Time: 10:00
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 2.0
Estimates of CVi 7.5
Calculated Confidence Intervals of CVi Lower: 4.70, Upper: 12.36
Estimates of CVg 34.4
Calculated Confidence Intervals of CVg Lower: 21.22, Upper: 84.88
Analytical CV 5.1
Calculated Confidence Intervals of Analytical CV Lower: 3.90, Upper: 7.36
Measurand Mean 10.9
Measurand Min
Measurand Max
Measurand SD