EFLM Biological Varation Database : BIVAC Minimum Data Set for C-terminal cross-linked telopeptide of type I collagen (CTX) EFLM Biological Variation

C-terminal cross-linked telopeptide of type I collagen (CTX)

Reference

Clowes JA, Hannon RA, Yap TS et al, 2002, Bone, 30(6), 886-90 , Effect of feeding on bone turnover markers and its impact on biological variability of measurements

Scoring

Total Score

C_7,8,10,12,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	C
8. Outlier Analysis	C
9. Normality	A
10. Variance Homogeneity	C
11. ANOVA	A
12. CI	C
13. No of Results	C
14. Concentrations	B
15. Total Score	C_7,8,10,12,13
Comment

Item Details

Parameter	Score
Matrix	Serum
Measurand	C-terminal cross-linked telopeptide of type I collagen (CTX)
Unit	Unknown / _
Overall Analytical Principle Method	Immunoassay; Non-competitive
Number of Subjects	20
Number of Subjects included in BV estimation	11
Ethinicity	Caucasian
Age Mean / Median	33.0
Age Min	21.0
Age Max	45.0
Age SD
Number of Males
Number of Females	20
State of Well Being	Healthy (excl pregnant)
Study Duration Length	10
Study Duration Units	Day
Sampling Intervals, e.g. X sample(s) per Interval Unit	1
Interval Units	Day
Sampling Times	Start Time: 9:00 End Time:
Number of Samples	5
Average Number of Samples Used for BV Estimation	5.0
Average Number of Replicates	2.0
Estimates of CVi	19.1
Calculated Confidence Intervals of CVi	Lower: 15.81, Upper: 24.13
Estimates of CVg
Calculated Confidence Intervals of CVg	Lower: 0.00, Upper:
Analytical CV	1.1
Calculated Confidence Intervals of Analytical CV	Lower: 0.93, Upper: 1.35
Measurand Mean
Measurand Min
Measurand Max
Measurand SD

Coding

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