Alkaline phosphatase (ALP) bone isoenzyme


Hannon R, Blumsohn A, Naylor K, Eastell R., 1998, J Bone Mineral Res, 13, 1124-33 , Response of biochemical markers of bone turnover to hormone replacement therapy: impact of biological variability


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score C10

Item Details

Parameter Score
Matrix Serum
Measurand Alkaline phosphatase (ALP) bone isoenzyme
Unit IU / L
Overall Analytical Principle Method Immunoassay; RIA
Number of Subjects 11
Number of Subjects included in BV estimation 11
Ethinicity Unknown
Age Mean / Median
Age Min 49.0
Age Max 56.0
Age SD
Number of Males
Number of Females 11
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length 24
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 9:00
End Time: 10:00
Number of Samples 24
Average Number of Samples Used for BV Estimation 24.0
Average Number of Replicates 1.0
Estimates of CVi 9.0
Calculated Confidence Intervals of CVi Lower: 8.03, Upper: 9.99
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: 0.00, Upper:
Analytical CV 3.4
Calculated Confidence Intervals of Analytical CV Lower: 2.68, Upper: 4.66
Measurand Mean 14.3
Measurand Min 10.3
Measurand Max 21.0
Measurand SD