N-telopeptide crosslinks (NTx)


Hannon R, Blumsohn A, Naylor K, Eastell R., 1998, J Bone Mineral Res, 13, 1124-33 , Response of biochemical markers of bone turnover to hormone replacement therapy: impact of biological variability

Originally from this reference: J Bone Mineral Res, Hannon R, Blumsohn A, Naylor K, Eastell R., 1998

ID: 0067


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score C10

Item Details

Parameter Score
Matrix Urine
Measurand N-telopeptide crosslinks (NTx)
Unit nmol / mmol
Overall Analytical Principle Method Immunoassay; RIA
Number of Subjects 11
Number of Subjects included in BV estimation 11
Ethinicity Unknown
Age Mean / Median
Age Min 49.0
Age Max 56.0
Age SD
Number of Males
Number of Females 11
State of Well Being Non-healthy (excl pregnant)
Study Duration Length 24
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 9:00
End Time: 10:00
Number of Samples 24
Average Number of Samples Used for BV Estimation 24.0
Average Number of Replicates 1.0
Estimates of CVi 24.3
Calculated Confidence Intervals of CVi Lower: 21.58, Upper: 27.01
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: 0.00, Upper:
Analytical CV 9.6
Calculated Confidence Intervals of Analytical CV Lower: 7.56, Upper: 13.16
Measurand Mean 51.9
Measurand Min 21.8
Measurand Max 120.0
Measurand SD


Parameter Score
Healthy Population false
Adult Population true
Weekly Samplings true
Reviewed true
Published true
Gender for Meta-Analysis Females
Snomed CT
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