Included in meta analysis


Beck Jensen JE, Sorensen HA, Kollerup G, Jensen LB, Sor ensen OH, 1994, Scand J Clin Lab Invest, 54(Sup219), 36-9 , Biological variation of biochemical bone markers


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand C
5. Pre-Analytical C
6. Replicate Analysis B
7. Steady State A
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations B
15. Total Score C4,5,8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Osteocalcin
Unit Unknown / Unknown
Overall Analytical Principle Method Immunoassay; ELISA
Number of Subjects 11
Number of Subjects included in BV estimation 11
Ethinicity Unknown
Age Mean / Median 58.0
Age Min
Age Max
Age SD
Number of Males
Number of Females 11
State of Well Being
Healthy (excl pregnant)
Study Duration Length 4
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:00
End Time: 09:00
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 1.0
Estimates of CVi 5.4
Calculated Confidence Intervals of CVi Lower: 0.00, Upper: 10.21
Estimates of CVg 20.5
Calculated Confidence Intervals of CVg Lower: 14.12, Upper: 35.38
Analytical CV 8.0
Calculated Confidence Intervals of Analytical CV Lower: 4.79, Upper: 22.99
Measurand Mean
Measurand Min
Measurand Max
Measurand SD