N-telopeptide crosslinks (NTx)


Clowes JA, Hannon RA, Yap TS et al, 2002, Bone, 30(6), 886-90 , Effect of feeding on bone turnover markers and its impact on biological variability of measurements


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State C
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations B
15. Total Score C7,8,10,12,13

Item Details

Parameter Score
Matrix 2 Hour Urine
Measurand N-telopeptide crosslinks (NTx)
Unit Unknown / _
Overall Analytical Principle Method Immunoassay; ELISA
Number of Subjects 20
Number of Subjects included in BV estimation 11
Ethinicity Caucasian
Age Mean / Median 33.0
Age Min 21.0
Age Max 45.0
Age SD
Number of Males
Number of Females 20
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Day
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Day
Sampling Times Start Time: 8:00
End Time: 10:00
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 43.7
Calculated Confidence Intervals of CVi Lower: 36.07, Upper: 55.33
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: 0.00, Upper:
Analytical CV 6.9
Calculated Confidence Intervals of Analytical CV Lower: 5.82, Upper: 8.48
Measurand Mean
Measurand Min
Measurand Max
Measurand SD