Pineda-Tenor D , Laserna-Mendieta EJ, Timon-Zapata J, Rodelgo-Jimenez L, Ramos-Corral R, Recio-Montealegre A and Gomez-Serranillos Reus M, 2013, Clin Chem Lab Med, 51, 851-62 , Biological variation and reference change value of common clinical chemistry and haematologic laboratory analytes in the eldery population


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score C7,8

Item Details

Parameter Score
Matrix Whole Blood EDTA
Measurand Thrombocytes
Unit 10(9) / L
Overall Analytical Principle Method Flow cytometry - Laser
Number of Subjects 64
Number of Subjects included in BV estimation 64
Ethinicity Unknown
Age Mean / Median
Age Min 80.0
Age Max 92.0
Age SD
Number of Males 0
Number of Females 64
State of Well Being
Healthy (excl pregnant)
Study Duration Length 4
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08.00
End Time: 10.00
Number of Samples 4
Average Number of Samples Used for BV Estimation 3.94
Average Number of Replicates 1.0
Estimates of CVi 13.7
Calculated Confidence Intervals of CVi Lower: 12.42, Upper: 15.26
Estimates of CVg 14.2
Calculated Confidence Intervals of CVg Lower: 0.00, Upper: 17.81
Analytical CV 1.8
Calculated Confidence Intervals of Analytical CV Lower: 1.37, Upper: 2.63
Measurand Mean 234.95
Measurand Min
Measurand Max
Measurand SD