Bui HN, Sluss PM, Hayes FJ, Blincko S, Knol DL, Blankestein MA and Heijboer AC, 2015, Clin Chim Acta, 450, 227-32 , Testosterone, free testosterone and free androgen index in women: reference intervals, biological variation and diagnostic value in polycystic ovary syndrome


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical C
6. Replicate Analysis C
7. Steady State B
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C5,6,8,10,11,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Testosterone
Unit ng / dL
Overall Analytical Principle Method MS; HPLC-MS
Number of Subjects 27
Number of Subjects included in BV estimation 25
Ethinicity Caucasian
Age Mean / Median 26.7
Age Min 18.0
Age Max 35.0
Age SD
Number of Males 0
Number of Females 27
State of Well Being
Healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Day
Sampling Times Start Time: 07:00
End Time: 12:00
Number of Samples
Average Number of Samples Used for BV Estimation 25.0
Average Number of Replicates
Estimates of CVi 21.0
Calculated Confidence Intervals of CVi Lower: , Upper:
Estimates of CVg 33.0
Calculated Confidence Intervals of CVg Lower: 0.00, Upper:
Analytical CV
Calculated Confidence Intervals of Analytical CV Lower: , Upper:
Measurand Mean
Measurand Min
Measurand Max
Measurand SD