Yang D, Zhou Y and Yang C, 2017, Int J lab Hemat, 39, e37-e40 , Daytime biological variation of hematological parameters in a healthy Chinese population


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical B
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C10,13

Item Details

Parameter Score
Matrix Whole Blood EDTA
Measurand Lymphocytes
Unit 10(9) / L
Overall Analytical Principle Method Flow cytometry - Laser
Number of Subjects 41
Number of Subjects included in BV estimation 41
Ethinicity Asian
Age Mean / Median
Age Min 21.0
Age Max 49.0
Age SD
Number of Males 21
Number of Females 20
State of Well Being
Healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Day
Sampling Intervals, e.g. X sample(s) per Interval Unit 3
Interval Units Hour
Sampling Times Start Time: 06.30
End Time: 18.30
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 16.4
Calculated Confidence Intervals of CVi Lower: 14.78, Upper: 18.41
Estimates of CVg 22.8
Calculated Confidence Intervals of CVg Lower: 18.26, Upper: 29.65
Analytical CV 2.7
Calculated Confidence Intervals of Analytical CV Lower: 2.46, Upper: 2.99
Measurand Mean 2.09
Measurand Min
Measurand Max
Measurand SD