Yang D, Zhou Y and Yang C, 2017, Int J lab Hemat, 39, e37-e40 , Daytime biological variation of hematological parameters in a healthy Chinese population


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical B
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C10,13

Item Details

Parameter Score
Matrix Whole Blood EDTA
Measurand Erythrocytes
Unit 10(12) / L
Overall Analytical Principle Method Flow cytometry - Laser
Number of Subjects 20
Number of Subjects included in BV estimation 20
Ethinicity Asian
Age Mean / Median 26.0
Age Min 21.0
Age Max 49.0
Age SD
Number of Males 0
Number of Females 20
State of Well Being
Healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Day
Sampling Intervals, e.g. X sample(s) per Interval Unit 3
Interval Units Hour
Sampling Times Start Time: 06.30
End Time: 18.30
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 2.6
Calculated Confidence Intervals of CVi Lower: 2.25, Upper: 3.08
Estimates of CVg 7.3
Calculated Confidence Intervals of CVg Lower: 5.53, Upper: 10.61
Analytical CV 0.5
Calculated Confidence Intervals of Analytical CV Lower: 0.44, Upper: 0.58
Measurand Mean 4.29
Measurand Min
Measurand Max
Measurand SD