EFLM Biological Varation Database : BIVAC Minimum Data Set for Estradiol EFLM Biological Variation

Estradiol

Reference

Ahokoski O, Virtanen A, Huupponene R, Scheinin H, Salminen E, Kairisto V, Irjala K, 1998, Clin Chem Lab Med, 36, 485-91 , Biological day-to-day variation and daytime changes of testosterone, follitropin, lutropin and oestradiol-17β in healthy men

Originally from this reference: Clin Chem Lab Med, Ahokoski O, Virtanen A, Huupponene R, Scheinin H, Salminen E, Kairisto V, Irjala K, 1998

ID: 0170

Scoring

Total Score

C_4,7,8,10,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	C
5. Pre-Analytical	A
6. Replicate Analysis	B
7. Steady State	C
8. Outlier Analysis	C
9. Normality	A
10. Variance Homogeneity	C
11. ANOVA	A
12. CI	A
13. No of Results	C
14. Concentrations	B
15. Total Score	C_4,7,8,10,13
Comment

Item Details

Parameter	Score
Matrix	Serum
Measurand	Estradiol
Unit	pmol / L
Overall Analytical Principle Method	Unknown
Number of Subjects	8
Number of Subjects included in BV estimation	8
Ethinicity	Unknown
Age Mean / Median	23.0
Age Min	20.0
Age Max	34.0
Age SD
Number of Males	8
Number of Females	0
State of Well Being	Healthy (excl pregnant)
Study Duration Length	2
Study Duration Units	Day
Sampling Intervals, e.g. X sample(s) per Interval Unit	4
Interval Units	Hour
Sampling Times	Start Time: 08.00 End Time: 20.00
Number of Samples	8
Average Number of Samples Used for BV Estimation	8.0
Average Number of Replicates	1.0
Estimates of CVi	14.3
Calculated Confidence Intervals of CVi	Lower: 9.58, Upper: 17.95
Estimates of CVg	9.9
Calculated Confidence Intervals of CVg	Lower: 5.21, Upper: 20.88
Analytical CV	5.3
Calculated Confidence Intervals of Analytical CV	Lower: 3.42, Upper: 11.67
Measurand Mean
Measurand Min
Measurand Max
Measurand SD

Coding

Parameter	Score
Healthy Population	true
Adult Population	true
Weekly Samplings	false
Reviewed	true
Published	true
Gender for Meta-Analysis	Males
Snomed CT
NPU
LOINC
Comment	Within and between day variation

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