Jayagopal V, Kilpatrick ES, Jennings PE, Hepburn DA and Atkin SL, 2003, J Clin Endocrinol Metab, 88(4), 1528-33 , The Biological Variation of Testosterone and Sex Hormone-Binding Globulin (SHBG) in Polycystic Ovarian Syndrome: Implications for SHBG as a Surrogate Marker of Insulin Resistance


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity A
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C8,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Testosterone
Unit nmol / L
Overall Analytical Principle Method Chemiluminescence
Number of Subjects 12
Number of Subjects included in BV estimation
Ethinicity Caucasian
Age Mean / Median 28.0
Age Min 18.0
Age Max 31.0
Age SD
Number of Males
Number of Females 12
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length 40
Study Duration Units Day
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Week
Sampling Times Start Time: 8
End Time: 9
Number of Samples 10
Average Number of Samples Used for BV Estimation 10.0
Average Number of Replicates 2.0
Estimates of CVi 30.7
Calculated Confidence Intervals of CVi Lower: 27.04, Upper: 35.48
Estimates of CVg 64.1
Calculated Confidence Intervals of CVg Lower: 45.44, Upper: 106.58
Analytical CV 5.2
Calculated Confidence Intervals of Analytical CV Lower: 4.62, Upper: 5.95
Measurand Mean 4.69
Measurand Min 3.93
Measurand Max 5.45
Measurand SD