Jayagopal V, Kilpatrick ES, Jennings PE, Hepburn DA and Atkin SL, 2003, J Clin Endocrinol Metab, 88(4), 1528-33 , The Biological Variation of Testosterone and Sex Hormone-Binding Globulin (SHBG) in Polycystic Ovarian Syndrome: Implications for SHBG as a Surrogate Marker of Insulin Resistance


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity A
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C8,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Testosterone
Unit nmol / L
Overall Analytical Principle Method Chemiluminescence
Number of Subjects 12
Number of Subjects included in BV estimation
Ethinicity Caucasian
Age Mean / Median 28.0
Age Min 18.0
Age Max 31.0
Age SD
Number of Males
Number of Females 12
State of Well Being Non-healthy (excl pregnant)
Study Duration Length 40
Study Duration Units Day
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Week
Sampling Times Start Time: 8
End Time: 9
Number of Samples 10
Average Number of Samples Used for BV Estimation 10.0
Average Number of Replicates 2.0
Estimates of CVi 30.7
Calculated Confidence Intervals of CVi Lower: 27.04, Upper: 35.48
Estimates of CVg 64.1
Calculated Confidence Intervals of CVg Lower: 45.44, Upper: 106.58
Analytical CV 5.2
Calculated Confidence Intervals of Analytical CV Lower: 4.62, Upper: 5.95
Measurand Mean 4.69
Measurand Min 3.93
Measurand Max 5.45
Measurand SD


© 2018 - 2019 This website and its content is copyright of EFLM. All rights reserved. Any redistribution or reproduction of part or all of the contents in any form is prohibited other than the following: you may print or download to a local hard disk extracts for your personal and non-commercial use only you may copy the content to individual third parties for their personal use, but only if you acknowledge the website as the source of the material You may not, except with our express written permission, distribute or commercially exploit the content. Nor may you transmit it or store it in any other website or other form of electronic retrieval system.
European Federation of Clinical Chemistry and Laboratory Medicine
Ms Silvia Cattaneo
Via Carlo Farini 81
20159 Milano - Italy