Reference
Jayagopal V, Kilpatrick ES, Jennings PE, Hepburn DA and Atkin SL, 2003, J Clin Endocrinol Metab, 88(4), 1528-33 , The Biological Variation of Testosterone and Sex Hormone-Binding Globulin (SHBG) in Polycystic Ovarian Syndrome: Implications for SHBG as a Surrogate Marker of Insulin Resistance
| Parameter | Score |
|---|---|
| 1. Scale | A |
| 2. Study Population | A |
| 3. Samples | A |
| 4. Measurand | A |
| 5. Pre-Analytical | A |
| 6. Replicate Analysis | A |
| 7. Steady State | A |
| 8. Outlier Analysis | C |
| 9. Normality | A |
| 10. Variance Homogeneity | A |
| 11. ANOVA | B |
| 12. CI | C |
| 13. No of Results | C |
| 14. Concentrations | A |
| 15. Total Score | C8,12,13 |
| Comment |
| Parameter | Score |
|---|---|
| Matrix | Serum |
| Measurand | Sexual-hormone-binding-globulin (SHBG) |
| Unit | nmol / L |
| Overall Analytical Principle Method | Chemiluminescence |
| Number of Subjects | 11 |
| Number of Subjects included in BV estimation | |
| Ethinicity | Caucasian |
| Age Mean / Median | 30.0 |
| Age Min | 19.0 |
| Age Max | 33.0 |
| Age SD | |
| Number of Males | |
| Number of Females | 11 |
| State of Well Being |
Healthy (excl pregnant)
|
| Diseases | |
| Study Duration Length | 40 |
| Study Duration Units | Day |
| Sampling Intervals, e.g. X sample(s) per Interval Unit | 2 |
| Interval Units | Week |
| Sampling Times | Start Time:
8
End Time: 9 |
| Number of Samples | 10 |
| Average Number of Samples Used for BV Estimation | 10.0 |
| Average Number of Replicates | 2.0 |
| Estimates of CVi | 4.3 |
| Calculated Confidence Intervals of CVi | Lower: 3.76, Upper: 5.01 |
| Estimates of CVg | 94.7 |
| Calculated Confidence Intervals of CVg | Lower: 0.00, Upper: 160.80 |
| Analytical CV | 1.0 |
| Calculated Confidence Intervals of Analytical CV | Lower: 0.88, Upper: 1.15 |
| Measurand Mean | 64.51 |
| Measurand Min | 56.86 |
| Measurand Max | 72.16 |
| Measurand SD |