EFLM Biological Varation Database : BIVAC Minimum Data Set for Sexual-hormone-binding-globulin (SHBG) EFLM Biological Variation

Sexual-hormone-binding-globulin (SHBG)

Reference

Collier CP, Morales A, Clark A, Lam M, Wynne-Edwards K and Black A, 2010, J Urol, 183, 2294-9 , The significance of biological variation in the diagnosis of testosterone deficiency, and consideration of the relevance of total, free and bioavailable testosterone determinations

Originally from this reference: J Urol, Collier CP, Morales A, Clark A, Lam M, Wynne-Edwards K and Black A, 2010

ID: 0394

Scoring

Total Score

C_3,8,10,11,12

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	C
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	A
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	C
11. ANOVA	C
12. CI	C
13. No of Results	A
14. Concentrations	A
15. Total Score	C_3,8,10,11,12
Comment

Item Details

Parameter	Score
Matrix	Unknown
Measurand	Sexual-hormone-binding-globulin (SHBG)
Unit	ng / dL
Overall Analytical Principle Method	Immunoassay; Competitive
Number of Subjects	87
Number of Subjects included in BV estimation	87
Ethinicity	Caucasian
Age Mean / Median
Age Min	50.0
Age Max	80.0
Age SD
Number of Males	87
Number of Females
State of Well Being	Healthy (excl pregnant)
Study Duration Length	4
Study Duration Units	Week
Sampling Intervals, e.g. X sample(s) per Interval Unit	3
Interval Units	Month
Sampling Times	Start Time: 7 End Time: 22
Number of Samples	3
Average Number of Samples Used for BV Estimation	3.0
Average Number of Replicates	1.0
Estimates of CVi	9.1
Calculated Confidence Intervals of CVi	Lower: 7.84, Upper: 10.38
Estimates of CVg	34.1
Calculated Confidence Intervals of CVg	Lower: 29.56, Upper: 40.20
Analytical CV	4.0
Calculated Confidence Intervals of Analytical CV	Lower: 3.15, Upper: 5.48
Measurand Mean
Measurand Min
Measurand Max
Measurand SD

Coding

Parameter	Score
Healthy Population	true
Adult Population	false
Weekly Samplings	true
Reviewed	true
Published	true
Gender for Meta-Analysis	Males
Snomed CT
NPU
LOINC
Comment

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