EFLM Biological Varation Database : BIVAC Minimum Data Set for Total thyroxine level EFLM Biological Variation

Total thyroxine level

Reference

Browning MC, Bennet WM, Kirkaldy AJ, Jung RT., 1988, Clin Chem, 34(4), 696-9 , Intra-individual variation of thyroxin, triiodothyronine, and thyrotropin in treated hypothyroid patients: implications for monitoring replacement therapy.

Originally from this reference: Clin Chem, Browning MC, Bennet WM, Kirkaldy AJ, Jung RT., 1988

ID: 0019

Scoring

Total Score

C_8,12

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	B
8. Outlier Analysis	C
9. Normality	A
10. Variance Homogeneity	A
11. ANOVA	A
12. CI	C
13. No of Results	A
14. Concentrations	A
15. Total Score	C_8,12
Comment

Item Details

Parameter	Score
Matrix	Serum
Measurand	Total thyroxine level
Unit	nmol / L
Overall Analytical Principle Method	Immunoassay; RIA
Number of Subjects	12
Number of Subjects included in BV estimation	12
Ethinicity	Caucasian
Age Mean / Median
Age Min	32.0
Age Max	76.0
Age SD
Number of Males	1
Number of Females	11
State of Well Being	Non-healthy (excl pregnant)
Study Duration Length	8
Study Duration Units	Hour
Sampling Intervals, e.g. X sample(s) per Interval Unit	2
Interval Units	Hour
Sampling Times	Start Time: End Time:
Number of Samples	6
Average Number of Samples Used for BV Estimation	6.0
Average Number of Replicates	2.0
Estimates of CVi	5.1
Calculated Confidence Intervals of CVi	Lower: , Upper:
Estimates of CVg
Calculated Confidence Intervals of CVg	Lower: 0.00, Upper:
Analytical CV
Calculated Confidence Intervals of Analytical CV	Lower: , Upper:
Measurand Mean	118.0
Measurand Min
Measurand Max
Measurand SD

Coding

Parameter	Score
Healthy Population	false
Adult Population	true
Weekly Samplings	false
Reviewed	true
Published	true
Gender for Meta-Analysis	Mixed
Snomed CT
NPU
LOINC
Comment

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