Thyroxine - total (T4)

Included in meta analysis

Reference

Reference
Browning MC, Ford RP, Callaghan SJ, Fraser CG., 1986, Clin Chem. 32(6):962-6., 32(6), 962-6 , Intra- and interindividual biological variation of five analytes used in assessing thyroid function: implications for necessary standards of performance and the interpretation of results.

Scoring

Total Score

C8,10,13

Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
11. ANOVA A
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C8,10,13
Comment

Item Details

Parameter Score
Matrix Serum
Measurand Thyroxine - total (T4)
Unit nmol / L
Overall Analytical Principle Method Immunoassay; RIA
Number of Subjects 12
Number of Subjects included in BV estimation 12
Ethinicity Caucasian
Age Mean / Median
Age Min 22.0
Age Max 46.0
Age SD
Number of Males 6
Number of Females 6
State of Well Being
Healthy (excl pregnant)
Diseases
Study Duration Length 5
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Week
Sampling Times Start Time:
End Time:
Number of Samples 10
Average Number of Samples Used for BV Estimation 10.0
Average Number of Replicates 2.0
Estimates of CVi 4.9
Calculated Confidence Intervals of CVi Lower: 4.00, Upper: 5.94
Estimates of CVg 12.2
Calculated Confidence Intervals of CVg Lower: 8.65, Upper: 20.28
Analytical CV 4.4
Calculated Confidence Intervals of Analytical CV Lower: 3.91, Upper: 5.04
Measurand Mean 92.0
Measurand Min
Measurand Max
Measurand SD

Coding