Neuron specific enolase

Included in meta analysis


Carobene A, Guerra E, Locatelli M et al , 2018, Clin Chem, 64, 1537-9 , Providing correct estimates of Biological Variation-not an easy task. The exemple of S100-β Protein and Neuron-Specific Enolase


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand Neuron specific enolase
Unit ug / L
Overall Analytical Principle Method Immunoassay; Not specified
Number of Subjects 89
Number of Subjects included in BV estimation 89
Ethinicity Caucasian
Age Mean / Median 38.0
Age Min 21.0
Age Max 69.0
Age SD
Number of Males 37
Number of Females 52
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time:
End Time:
Number of Samples 10
Average Number of Samples Used for BV Estimation 9.07
Average Number of Replicates 1.99
Estimates of CVi 10.9
Calculated Confidence Intervals of CVi Lower: 10.35, Upper: 11.51
Estimates of CVg 20.3
Calculated Confidence Intervals of CVg Lower: 17.61, Upper: 23.90
Analytical CV 2.3
Calculated Confidence Intervals of Analytical CV Lower: 2.19, Upper: 2.42
Measurand Mean 11.9
Measurand Min 11.8
Measurand Max 12.1
Measurand SD