Wu AHB, Ruan W, Todd J and Lynch KL, 2014, Clinica Chimica Acta, 430, 43-7 , Biological variation of β-sitosterol, campesterol, and lathosterol as cholesterol absorption and synthesis biomarkers.


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI C
13. No of Results A
14. Concentrations A
15. Total Score C8,10,12

Item Details

Parameter Score
Matrix Serum
Measurand Cholesterol
Unit mmol / L
Overall Analytical Principle Method Enzymatic analysis - Not specified
Number of Subjects 25
Number of Subjects included in BV estimation 25
Ethinicity Caucasian
Age Mean / Median
Age Min 24.0
Age Max 61.0
Age SD
Number of Males 10
Number of Females 15
State of Well Being
Healthy (excl pregnant)
Study Duration Length 6
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:10
End Time:
Number of Samples 6
Average Number of Samples Used for BV Estimation 6.0
Average Number of Replicates 1.0
Estimates of CVi 7.1
Calculated Confidence Intervals of CVi Lower: 6.27, Upper: 8.15
Estimates of CVg 16.0
Calculated Confidence Intervals of CVg Lower: 12.41, Upper: 22.26
Analytical CV 1.5
Calculated Confidence Intervals of Analytical CV Lower: 1.11, Upper: 2.32
Measurand Mean
Measurand Min
Measurand Max
Measurand SD