Rohlfing C, Wiedmeyer HM, Little R, Grotz VL, Tennill A, England J, Madsen R, Goldstein D, 2002, Clin Chem, 48, 1116-8 , Biological variaiton of glycohemoglobin.


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C8,10,13

Item Details

Parameter Score
Matrix Plasma
Measurand Glucose
Unit mmol / L
Overall Analytical Principle Method Spectrophotometry; Enzymatic
Number of Subjects 48
Number of Subjects included in BV estimation 45
Ethinicity Caucasian
Age Mean / Median
Age Min
Age Max
Age SD
Number of Males 48
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 12
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time:
End Time:
Number of Samples 12
Average Number of Samples Used for BV Estimation 12.0
Average Number of Replicates 1.0
Estimates of CVi 5.7
Calculated Confidence Intervals of CVi Lower: 5.32, Upper: 6.11
Estimates of CVg 5.8
Calculated Confidence Intervals of CVg Lower: 4.71, Upper: 7.42
Analytical CV 1.7
Calculated Confidence Intervals of Analytical CV Lower: 1.43, Upper: 2.09
Measurand Mean 95.4
Measurand Min
Measurand Max
Measurand SD