Aarsand AK, Diaz-Garzón J, Fernández-Calle P, et al, 2018, Clin Chem, 64(9), 1380-93 , The EuBIVAS: within- and between-subject biological variation data for electrolytes, lipids, urea, uric acid, total protein, total bilirubin, direct bilirubin and glucose


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand Urea
Unit mg / dL
Overall Analytical Principle Method Spectrophotometry; Enzymatic
Number of Subjects 43
Number of Subjects included in BV estimation 43
Ethinicity Caucasian
Age Mean / Median 34.0
Age Min 21.0
Age Max 49.0
Age SD
Number of Males
Number of Females 43
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:00
End Time: 10:00
Number of Samples 10
Average Number of Samples Used for BV Estimation 9.21
Average Number of Replicates 1.99
Estimates of CVi 15.7
Calculated Confidence Intervals of CVi Lower: 14.61, Upper: 16.96
Estimates of CVg 19.7
Calculated Confidence Intervals of CVg Lower: 16.01, Upper: 25.28
Analytical CV 2.32
Calculated Confidence Intervals of Analytical CV Lower: 2.17, Upper: 2.50
Measurand Mean 28.0
Measurand Min 27.4
Measurand Max 28.5
Measurand SD