Included in meta analysis


Sandberg S, Rustad P, Johannesen B, Stolness B, 1998, Eur J Haematol, 61, 42-8 , Within-subject biological variation of reticulocytes and reticulocyte – derived parameters


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand B
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality B
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score B4,9,11

Item Details

Parameter Score
Matrix Whole Blood EDTA
Measurand Reticulocytes
Unit 10(9) / L
Overall Analytical Principle Method Flow cytometry - Laser
Number of Subjects 13
Number of Subjects included in BV estimation 12
Ethinicity Caucasian
Age Mean / Median
Age Min 27.0
Age Max 51.0
Age SD
Number of Males 5
Number of Females 8
State of Well Being
Healthy (excl pregnant)
Study Duration Length 6
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08.00
End Time: 10:00
Number of Samples 7
Average Number of Samples Used for BV Estimation 6.3
Average Number of Replicates 2.0
Estimates of CVi 11.0
Calculated Confidence Intervals of CVi Lower: 9.31, Upper: 13.40
Estimates of CVg 26.0
Calculated Confidence Intervals of CVg Lower: 18.37, Upper: 43.31
Analytical CV 2.9
Calculated Confidence Intervals of Analytical CV Lower: 2.49, Upper: 3.47
Measurand Mean 0.058
Measurand Min
Measurand Max
Measurand SD