Cystatin C


Thyagarajan B, Howard AG, Durazo-Arvizu R, Eckfeldt JH, Gellman MD, Kim RS, Liu K, Mendez AJ, Penedo FJ, Talavera GA, Youngblood ME, Zhao L and Sotres-Alvarez D, 2016, Clin Chim Acta, 463, 129-137 , Analytical and biological variability in biomarker measurement in the Hispanic Community Health Study/Study of Latinos


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis B
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results B
14. Concentrations A
15. Total Score C10
Comment 1) Data may not be used for estimation of RCV (9B). 2) Data is not necessarily representative for the total population (10C).

Item Details

Parameter Score
Matrix Serum
Measurand Cystatin C
Unit mg / L
Overall Analytical Principle Method Unknown
Number of Subjects 49
Number of Subjects included in BV estimation 49
Ethinicity Hispanic or Latino
Age Mean / Median 46.0
Age Min 18.0
Age Max 74.0
Age SD
Number of Males 18
Number of Females 31
State of Well Being
Healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 2
Average Number of Samples Used for BV Estimation 2.0
Average Number of Replicates 2.0
Estimates of CVi 5.2
Calculated Confidence Intervals of CVi Lower: 4.18, Upper: 6.66
Estimates of CVg 25.6
Calculated Confidence Intervals of CVg Lower: 21.27, Upper: 32.04
Analytical CV 2.9
Calculated Confidence Intervals of Analytical CV Lower: 2.54, Upper: 3.37
Measurand Mean 0.81
Measurand Min
Measurand Max
Measurand SD