Cotlove E, Harris EK and Williams GZ, 1970, Clin Chem, 16, 1028-32 , Biological and analytic components of variation in long-term studies of serum constituents in normal subjects


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand D
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI NA
13. No of Results C
14. Concentrations A
15. Total Score D4
Comment only variances

Item Details

Parameter Score
Matrix Serum
Measurand Chloride
Unit mmol / L
Overall Analytical Principle Method Unknown
Number of Subjects 68
Number of Subjects included in BV estimation 68
Ethinicity Caucasian
Age Mean / Median
Age Min 20.0
Age Max 59.0
Age SD
Number of Males 33
Number of Females 35
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:30
End Time: 09:00
Number of Samples 11
Average Number of Samples Used for BV Estimation 11.0
Average Number of Replicates 2.0
Estimates of CVi
Calculated Confidence Intervals of CVi Lower: , Upper:
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: 0.82, Upper:
Analytical CV
Calculated Confidence Intervals of Analytical CV Lower: , Upper:
Measurand Mean
Measurand Min
Measurand Max
Measurand SD