EFLM Biological Varation Database : BIVAC Minimum Data Set for Cystatin C EFLM Biological Variation

Cystatin C

Reference

Carter JL, Parker CT, Stevens PE, Eaglestone G, Knight S, Farmer CT and Lamb EJ, 2016, Clin Chem, 62, 876-83 , Biological variation of plasma and unrinary markers of acute kidney injury in patients with chronic kidney disease

Scoring

Total Score

B_7,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	B
8. Outlier Analysis	A
9. Normality	A
10. Variance Homogeneity	A
11. ANOVA	A
12. CI	A
13. No of Results	B
14. Concentrations	A
15. Total Score	B_7,13
Comment

Item Details

Parameter	Score
Matrix	Plasma
Measurand	Cystatin C
Unit	mg / L
Overall Analytical Principle Method	Enzymatic analysis - Not specified
Number of Subjects	80
Number of Subjects included in BV estimation	80
Ethinicity	Unknown
Age Mean / Median	67.9
Age Min	33.8
Age Max	89.1
Age SD
Number of Males	47
Number of Females	33
State of Well Being	Non-healthy (excl pregnant)
Study Duration Length	6
Study Duration Units	Week
Sampling Intervals, e.g. X sample(s) per Interval Unit	1
Interval Units	Week
Sampling Times	Start Time: unknown End Time:
Number of Samples	6
Average Number of Samples Used for BV Estimation	6.0
Average Number of Replicates	2.0
Estimates of CVi	4.8
Calculated Confidence Intervals of CVi	Lower: 4.48, Upper: 5.16
Estimates of CVg	49.9
Calculated Confidence Intervals of CVg	Lower: 43.21, Upper: 59.05
Analytical CV	0.9
Calculated Confidence Intervals of Analytical CV	Lower: 0.85, Upper: 0.96
Measurand Mean	0.76
Measurand Min
Measurand Max
Measurand SD

Coding

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