Rivara MB, Zelnick LR, Hoofnagle AN, Newitt R, Tracy RP, Kratz M, Weigle DS and Kestenbaum BR, 2017, Clin Chem, 63, 915-23 , Diurnal and long-term variation in plasma concentrations and renal clearances of circulating markers of kidney proximal tubular secretion


Total Score


Parameter Score
1. Scale A
2. Study Population B
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score B2,6

Item Details

Parameter Score
Matrix Plasma
Measurand Creatinine
Unit mg / dL
Overall Analytical Principle Method Unknown
Number of Subjects 33
Number of Subjects included in BV estimation 25
Ethinicity Caucasian
Age Mean / Median
Age Min
Age Max
Age SD
Number of Males
Number of Females
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length 14
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 3
Interval Units Other
Sampling Times Start Time: 08:00
End Time: 08:00
Number of Samples 3
Average Number of Samples Used for BV Estimation 3.0
Average Number of Replicates 1.0
Estimates of CVi 7.1
Calculated Confidence Intervals of CVi Lower: 0.00, Upper: 10.66
Estimates of CVg 18.2
Calculated Confidence Intervals of CVg Lower: 13.76, Upper: 25.72
Analytical CV 7.5
Calculated Confidence Intervals of Analytical CV Lower: 4.96, Upper: 15.26
Measurand Mean 0.7
Measurand Min
Measurand Max
Measurand SD