Williams GZ, Widdowson GM and Penton J, 1978, Clin Chem, 24, 313-20 , Individual Character of Variation in Time-Series Studies of Healthy People II. Differences in Values for Clinical Chemical Analytes in Serum among Demographic Groups by Age and Sex


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Glucose
Unit mmol / L
Overall Analytical Principle Method Spectrophotometry; Enzymatic
Number of Subjects 142
Number of Subjects included in BV estimation 142
Ethinicity Caucasian
Age Mean / Median
Age Min 36.0
Age Max 55.0
Age SD
Number of Males
Number of Females 142
State of Well Being
Healthy (excl pregnant)
Study Duration Length 12
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 7:30
End Time: 10:00
Number of Samples 12
Average Number of Samples Used for BV Estimation 8.5
Average Number of Replicates 2.0
Estimates of CVi 6.6
Calculated Confidence Intervals of CVi Lower: 6.32, Upper: 6.91
Estimates of CVg 8.3
Calculated Confidence Intervals of CVg Lower: 7.36, Upper: 9.47
Analytical CV 2.2
Calculated Confidence Intervals of Analytical CV Lower: 2.11, Upper: 2.29
Measurand Mean 84.6
Measurand Min
Measurand Max
Measurand SD