Williams GZ, Widdowson GM and Penton J, 1978, Clin Chem, 24, 313-20 , Individual Character of Variation in Time-Series Studies of Healthy People II. Differences in Values for Clinical Chemical Analytes in Serum among Demographic Groups by Age and Sex

Originally from this reference: Clin Chem, Williams GZ, Widdowson GM and Penton J, 1978

ID: 0165


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Glucose
Unit mmol / L
Overall Analytical Principle Method Spectrophotometry; Enzymatic
Number of Subjects 270
Number of Subjects included in BV estimation 270
Ethinicity Caucasian
Age Mean / Median
Age Min 18.0
Age Max 35.0
Age SD
Number of Males 270
Number of Females
State of Well Being Healthy (excl pregnant)
Study Duration Length 12
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 7:30
End Time: 10:00
Number of Samples 12
Average Number of Samples Used for BV Estimation 8.5
Average Number of Replicates 2.0
Estimates of CVi 6.3
Calculated Confidence Intervals of CVi Lower: 5.06, Upper: 7.33
Estimates of CVg 6.7
Calculated Confidence Intervals of CVg Lower: 0.00, Upper: 7.25
Analytical CV 2.2
Calculated Confidence Intervals of Analytical CV Lower: 2.65, Upper: 2.65
Measurand Mean 86.4
Measurand Min
Measurand Max
Measurand SD


Parameter Score
Healthy Population true
Adult Population true
Weekly Samplings true
Reviewed true
Published true
Gender for Meta-Analysis Males
Snomed CT