Included in meta analysis


Ortolá J, Castiñeiras MJ, Fuentes-Arderiu X., 1992, Clin Chem, 38, 56-9 , Biological variation data applied to the selection of serum lipid ratios used as risk markers of coronary heart disease.


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State A
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity A
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C8,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Cholesterol
Unit mmol / L
Overall Analytical Principle Method Enzymatic analysis - Not specified
Number of Subjects 23
Number of Subjects included in BV estimation 23
Ethinicity Caucasian
Age Mean / Median
Age Min 20.0
Age Max 45.0
Age SD
Number of Males 23
Number of Females 0
State of Well Being
Healthy (excl pregnant)
Study Duration Length 14
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 12
Average Number of Samples Used for BV Estimation 11.5
Average Number of Replicates 1.0
Estimates of CVi 7.0
Calculated Confidence Intervals of CVi Lower: 6.42, Upper: 7.70
Estimates of CVg 15.4
Calculated Confidence Intervals of CVg Lower: 11.90, Upper: 21.70
Analytical CV 0.9
Calculated Confidence Intervals of Analytical CV Lower: 0.71, Upper: 1.24
Measurand Mean 5.33
Measurand Min
Measurand Max
Measurand SD