Sambasivan AS, Lepage N and Filler G, 2005, Clin Chem, 51, 2215-6 , Cystatin C intrapatient variability in children with chronic kidney disease is less than serum creatinine


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical B
6. Replicate Analysis C
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C6,8,10,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Creatinine
Unit micromol / L
Overall Analytical Principle Method Enzymatic analysis - Not specified
Number of Subjects 38
Number of Subjects included in BV estimation 38
Ethinicity Caucasian
Age Mean / Median 10.1
Age Min
Age Max
Age SD
Number of Males 19
Number of Females 19
State of Well Being
Healthy (excl pregnant)
Study Duration Length 18
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit
Interval Units Week
Sampling Times Start Time:
End Time:
Number of Samples 9
Average Number of Samples Used for BV Estimation
Average Number of Replicates 1.0
Estimates of CVi 13.0
Calculated Confidence Intervals of CVi Lower: 12.03, Upper: 14.14
Estimates of CVg 36.0
Calculated Confidence Intervals of CVg Lower: 29.31, Upper: 46.53
Analytical CV 1.8
Calculated Confidence Intervals of Analytical CV Lower: 1.46, Upper: 2.36
Measurand Mean 52.4
Measurand Min
Measurand Max
Measurand SD