EFLM Biological Varation Database : BIVAC Minimum Data Set for Cholesterol EFLM Biological Variation

Cholesterol

Reference

Kafonek SD, Derby CA and Bachorik PS, 1992, Clin Chem, 38, 864-72 , Biological variability of lipoproteins and apolipoproteins in patients referred to a lipid clinic

Scoring

Total Score

C_8,10,11,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	B
7. Steady State	A
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	C
11. ANOVA	C
12. CI	A
13. No of Results	C
14. Concentrations	A
15. Total Score	C_8,10,11,13
Comment

Item Details

Parameter	Score
Matrix	Plasma
Measurand	Cholesterol
Unit	mmol / L
Overall Analytical Principle Method	Spectrophotometry; UV/VISIBLE
Number of Subjects	27
Number of Subjects included in BV estimation	27
Ethinicity	Unknown
Age Mean / Median	51.0
Age Min
Age Max
Age SD
Number of Males	27
Number of Females
State of Well Being	Non-healthy (excl pregnant)
Study Duration Length	2
Study Duration Units	Year
Sampling Intervals, e.g. X sample(s) per Interval Unit
Interval Units	Week
Sampling Times	Start Time: End Time:
Number of Samples	3
Average Number of Samples Used for BV Estimation	3.0
Average Number of Replicates	1.0
Estimates of CVi	5.2
Calculated Confidence Intervals of CVi	Lower: 3.80, Upper: 6.56
Estimates of CVg
Calculated Confidence Intervals of CVg	Lower: 0.00, Upper:
Analytical CV	2.0
Calculated Confidence Intervals of Analytical CV	Lower: 1.35, Upper: 3.83
Measurand Mean	6.01
Measurand Min
Measurand Max
Measurand SD	0.8

Coding

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