S100 calcium-binding protein B (S100B)


Trapé J, Montesinos J, Franquesa J, Sala M, Fígols C, Miguel A and Domenech M, 2012, Clin Chem Lab Med, 50, 927-9 , Determination of the biological variation of S100 β and lactate dehydrogenase in disease-free patients with malignant melanoma


Total Score


Parameter Score
1. Scale A
2. Study Population B
3. Samples B
4. Measurand A
5. Pre-Analytical B
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C8,10,12,13

Item Details

Parameter Score
Matrix Serum
Measurand S100 calcium-binding protein B (S100B)
Unit ug / L
Overall Analytical Principle Method Immunoassay; Not specified
Number of Subjects 32
Number of Subjects included in BV estimation 32
Ethinicity Caucasian
Age Mean / Median 59.1
Age Min
Age Max
Age SD 14.8
Number of Males
Number of Females
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Year
Sampling Intervals, e.g. X sample(s) per Interval Unit 4
Interval Units Year
Sampling Times Start Time:
End Time:
Number of Samples
Average Number of Samples Used for BV Estimation 4.2
Average Number of Replicates
Estimates of CVi 14.2
Calculated Confidence Intervals of CVi Lower: 12.29, Upper: 16.58
Estimates of CVg 66.3
Calculated Confidence Intervals of CVg Lower: 53.15, Upper: 87.91
Analytical CV 3.5
Calculated Confidence Intervals of Analytical CV Lower: 2.51, Upper: 5.78
Measurand Mean 0.0557
Measurand Min
Measurand Max
Measurand SD