S100 calcium-binding protein B (S100B)


Johnson PR, Gwilt SC, Neville CG, 2018, Clinical Chemistry, 64, 866-88 , Estimates of Within-Person Biological Variation and Reference Change Values of Serum S100B and NSE Proteins.


Total Score


Parameter Score
1. Scale A
2. Study Population B
3. Samples A
4. Measurand A
5. Pre-Analytical B
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity A
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C7,8,12,13

Item Details

Parameter Score
Matrix Serum
Measurand S100 calcium-binding protein B (S100B)
Unit ug / L
Overall Analytical Principle Method Immunoassay; Not specified
Number of Subjects 40
Number of Subjects included in BV estimation 40
Ethinicity Unknown
Age Mean / Median 25.0
Age Min
Age Max
Age SD
Number of Males
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 3
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Other
Sampling Times Start Time:
End Time:
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 0.0
Estimates of CVi 18.9
Calculated Confidence Intervals of CVi Lower: 16.78, Upper: 21.64
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: 0.00, Upper:
Analytical CV 1.0
Calculated Confidence Intervals of Analytical CV Lower: 0.74, Upper: 1.52
Measurand Mean 48.0
Measurand Min
Measurand Max
Measurand SD