Tissue Polypeptide antigen (TPA)


Plebani M, Giacomini A, Beghi L, De Paoli M, Roveroni G, Galleotti F, Corsini A, Fraser CG, 1996, Anticancer Res, 16, 2249-52 , Serum tumor markers in monitoring patients: interpretation of results using analytical and biological variation


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State A
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C8,10,12,13
Comment C8,10,12

Item Details

Parameter Score
Matrix Serum
Measurand Tissue Polypeptide antigen (TPA)
Unit U / L
Overall Analytical Principle Method Immunoassay; RIA
Number of Subjects 22
Number of Subjects included in BV estimation 22
Ethinicity Caucasian
Age Mean / Median
Age Min
Age Max
Age SD
Number of Males 12
Number of Females 10
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length 2
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 3
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 6
Average Number of Samples Used for BV Estimation 6.0
Average Number of Replicates 1.0
Estimates of CVi 25.7
Calculated Confidence Intervals of CVi Lower: 22.55, Upper: 29.75
Estimates of CVg 144.7
Calculated Confidence Intervals of CVg Lower: 111.70, Upper: 205.08
Analytical CV 5.0
Calculated Confidence Intervals of Analytical CV Lower: 3.62, Upper: 8.06
Measurand Mean 69.0
Measurand Min
Measurand Max
Measurand SD