EFLM Biological Varation Database : BIVAC Minimum Data Set for Cancer antigen 19-9 (CA 19-9) EFLM Biological Variation

Cancer antigen 19-9 (CA 19-9)

Reference

Plebani M, Giacomini A, Beghi L, De Paoli M, Roveroni G, Galleotti F, Corsini A, Fraser CG, 1996, Anticancer Res, 16, 2249-52 , Serum tumor markers in monitoring patients: interpretation of results using analytical and biological variation

Scoring

Total Score

C_8,10,12,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	B
7. Steady State	A
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	C
11. ANOVA	B
12. CI	C
13. No of Results	C
14. Concentrations	A
15. Total Score	C_8,10,12,13
Comment	C8,10,12

Item Details

Parameter	Score
Matrix	Serum
Measurand	Cancer antigen 19-9 (CA 19-9)
Unit	ku / L
Overall Analytical Principle Method	Immunoassay; Not specified
Number of Subjects	17
Number of Subjects included in BV estimation	17
Ethinicity	Unknown
Age Mean / Median	30.0
Age Min
Age Max
Age SD
Number of Males	9
Number of Females	8
State of Well Being	Non-healthy (excl pregnant)
Study Duration Length	2
Study Duration Units	Month
Sampling Intervals, e.g. X sample(s) per Interval Unit	3
Interval Units	Month
Sampling Times	Start Time: End Time:
Number of Samples	6
Average Number of Samples Used for BV Estimation	6.0
Average Number of Replicates	1.0
Estimates of CVi	15.9
Calculated Confidence Intervals of CVi	Lower: 13.75, Upper: 18.78
Estimates of CVg	159.0
Calculated Confidence Intervals of CVg	Lower: 119.23, Upper: 238.48
Analytical CV	2.7
Calculated Confidence Intervals of Analytical CV	Lower: 1.89, Upper: 4.74
Measurand Mean	17.1
Measurand Min
Measurand Max
Measurand SD

Coding

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