Human epididymis protein 4 (HE4)

Included in meta analysis

Reference

Reference
Braga F, Ferraro S, Mozzi R and Panteghini M, 2014, Clin Chem Lab Med, 52, 1625-31 , The importance of individual biology in the clinical use of serum biomarkers for ovarian cancer

Scoring

Total Score

B7,8

Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis B
9. Normality A
10. Variance Homogeneity A
11. ANOVA A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score B7,8
Comment

Item Details

Parameter Score
Matrix Serum
Measurand Human epididymis protein 4 (HE4)
Unit pmol / L
Overall Analytical Principle Method Immunoassay; Not specified
Number of Subjects 28
Number of Subjects included in BV estimation 28
Ethinicity Caucasian
Age Mean / Median
Age Min 25.0
Age Max 68.0
Age SD
Number of Males 0
Number of Females 28
State of Well Being Healthy (excl pregnant)
Study Duration Length 4
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time: 09:00
End Time: 09:30
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 2.0
Estimates of CVi 9.7
Calculated Confidence Intervals of CVi Lower: 8.42, Upper: 11.43
Estimates of CVg 16.4
Calculated Confidence Intervals of CVg Lower: 12.65, Upper: 22.61
Analytical CV 0.98
Calculated Confidence Intervals of Analytical CV Lower: 0.87, Upper: 1.13
Measurand Mean 48.6
Measurand Min 31.3
Measurand Max 66.1
Measurand SD

Coding

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