Trapé J, Franquesa J, Sala M, Domenech M, Montesinos J, Catot S, Buxó J, Casado E, Fígols C, Harillo S, Galobart J and Bella M, 2010, Clin Chem Lab Med, 48, 1799-1801 , Determination of biological variation of -fetoprotein and choriogonadotropin ( chain) in disease-free patients with testicular cancer


Total Score


Parameter Score
1. Scale A
2. Study Population B
3. Samples C
4. Measurand A
5. Pre-Analytical C
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C3,5,7,8,10,11,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Alphafetoprotein
Unit ug / L
Overall Analytical Principle Method Chemiluminescence
Number of Subjects 28
Number of Subjects included in BV estimation 28
Ethinicity Unknown
Age Mean / Median 33.3
Age Min 24.46
Age Max 42.14
Age SD 8.84
Number of Males 28
Number of Females
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit
Interval Units Week
Sampling Times Start Time:
End Time:
Number of Samples
Average Number of Samples Used for BV Estimation
Average Number of Replicates
Estimates of CVi 12.4
Calculated Confidence Intervals of CVi Lower: 0.00, Upper: 450.74
Estimates of CVg 45.1
Calculated Confidence Intervals of CVg Lower: 0.00, Upper: 62.46
Analytical CV 7.1
Calculated Confidence Intervals of Analytical CV Lower: 3.70, Upper: 44.62
Measurand Mean 3.9
Measurand Min
Measurand Max
Measurand SD