Cancer antigen 19-9 (CA 19-9)

Included in meta analysis


Vestergaard EM, Hein HO, Meyer H, Grunnet N, Jorgensen J, Wolf H, Orntoft TF, 1999, Clin Chem, 45, 54-61 , Reference Values and Biological Variation for Tumor Marker CA 19-9 in Serum for Different Lewis and Secretor Genotypes and Evaluation of Secretor and Lewis Genotyping in a Caucasian Populatio


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical C
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations B
15. Total Score C5,10,13
Comment C5,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Cancer antigen 19-9 (CA 19-9)
Unit ku / L
Overall Analytical Principle Method Immunoassay; Not specified
Number of Subjects 500
Number of Subjects included in BV estimation 13
Ethinicity Caucasian
Age Mean / Median
Age Min 21.0
Age Max 69.0
Age SD
Number of Males 382
Number of Females 118
State of Well Being
Healthy (excl pregnant)
Study Duration Length 3
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time:
End Time:
Number of Samples 3
Average Number of Samples Used for BV Estimation 3.0
Average Number of Replicates 3.0
Estimates of CVi 15.8
Calculated Confidence Intervals of CVi Lower: 11.90, Upper: 22.29
Estimates of CVg 102.2
Calculated Confidence Intervals of CVg Lower: 73.79, Upper: 165.10
Analytical CV 9.8
Calculated Confidence Intervals of Analytical CV Lower: 8.47, Upper: 11.62
Measurand Mean
Measurand Min
Measurand Max
Measurand SD