EFLM Biological Varation Database : BIVAC Minimum Data Set for Prostate specific antigen (PSA) EFLM Biological Variation

Prostate specific antigen (PSA)

Reference

Panteghini M, Pagani F, Bonora R , 1992, Eur J Clin Chem Clin Biochem, 30, 135-9 , Pre-analytical and biological variability of prostatic acid phosphatase and Prostate-Specific Antigen in serum from patients with prostatic pathology

Originally from this reference: Eur J Clin Chem Clin Biochem, Panteghini M, Pagani F, Bonora R , 1992

ID: 0126

Scoring

Total Score

C_2,7,8,10,13

Parameter	Score
1. Scale	A
2. Study Population	C
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	C
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	C
11. ANOVA	B
12. CI	A
13. No of Results	C
14. Concentrations	B
15. Total Score	C_2,7,8,10,13
Comment	Diseased subjects. Not included in meta analysys

Item Details

Parameter	Score
Matrix	Serum
Measurand	Prostate specific antigen (PSA)
Unit	ug / L
Overall Analytical Principle Method	Immunoassay; Not specified
Number of Subjects	5
Number of Subjects included in BV estimation	5
Ethinicity	Unknown
Age Mean / Median
Age Min
Age Max
Age SD
Number of Males	5
Number of Females	0
State of Well Being	Non-healthy (excl pregnant)
Study Duration Length	4
Study Duration Units	Day
Sampling Intervals, e.g. X sample(s) per Interval Unit	2
Interval Units	Day
Sampling Times	Start Time: 07:00 End Time: 15:00
Number of Samples	8
Average Number of Samples Used for BV Estimation	8.0
Average Number of Replicates	8.0
Estimates of CVi	14.0
Calculated Confidence Intervals of CVi	Lower: 11.32, Upper: 18.30
Estimates of CVg
Calculated Confidence Intervals of CVg	Lower: 0.00, Upper:
Analytical CV	4.2
Calculated Confidence Intervals of Analytical CV	Lower: 3.88, Upper: 4.58
Measurand Mean
Measurand Min
Measurand Max
Measurand SD

Coding

Parameter	Score
Healthy Population	false
Adult Population	true
Weekly Samplings	false
Reviewed	true
Published	true
Gender for Meta-Analysis	Males
Snomed CT
NPU
LOINC
Comment	Should not be included in metananlysis

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