Cancer antigen 15-3 (CA 15.3)


Sölétormos G, Schioler V, Nielsen D, Skovsgaard T, Domnerbowsky P, 1993, Clin Chem, 39, 2077-83 , Interpretation of results for tumor markers on the basis of analytical imprecision an biological variation


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples B
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State A
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity A
12. CI C
13. No of Results C
14. Concentrations B
15. Total Score C8,12,13
Comment C8,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Cancer antigen 15-3 (CA 15.3)
Unit U / L
Overall Analytical Principle Method Immunoassay; RIA
Number of Subjects 22
Number of Subjects included in BV estimation 21
Ethinicity Caucasian
Age Mean / Median 49.0
Age Min 34.0
Age Max 63.0
Age SD
Number of Males 0
Number of Females 22
State of Well Being
Healthy (excl pregnant)
Study Duration Length 3
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 5
Interval Units Week
Sampling Times Start Time: 07:30
End Time: 09:00
Number of Samples 14
Average Number of Samples Used for BV Estimation 14.0
Average Number of Replicates 1.0
Estimates of CVi 6.2
Calculated Confidence Intervals of CVi Lower: 0.00, Upper: 9.48
Estimates of CVg 62.9
Calculated Confidence Intervals of CVg Lower: 48.35, Upper: 89.95
Analytical CV 11.2
Calculated Confidence Intervals of Analytical CV Lower: 8.92, Upper: 15.06
Measurand Mean
Measurand Min
Measurand Max
Measurand SD