Cancer antigen 72-4 (CA 72-4)

Included in meta analysis


Wang S, Zhao M, Mu R, Zhang X, Yun K and Shang H, 2018, J Clin Lab Anal, 32(4), e22327 , Biological variation of serum neuron-specific enolase and carbohydrate antigen 724 tumor markers


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score B7
Comment They should have checked the limit of detection. BV too high

Item Details

Parameter Score
Matrix Serum
Measurand Cancer antigen 72-4 (CA 72-4)
Unit ug / mL
Overall Analytical Principle Method Immunoassay; Not specified
Number of Subjects 20
Number of Subjects included in BV estimation 20
Ethinicity Caucasian
Age Mean / Median 29.0
Age Min 22.0
Age Max 49.0
Age SD
Number of Males 9
Number of Females 11
State of Well Being
Healthy (excl pregnant)
Study Duration Length 5
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 7:20
End Time: 8:10
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 50.3
Calculated Confidence Intervals of CVi Lower: 43.55, Upper: 59.54
Estimates of CVg 103.4
Calculated Confidence Intervals of CVg Lower: 77.71, Upper: 151.13
Analytical CV 4.0
Calculated Confidence Intervals of Analytical CV Lower: 3.51, Upper: 4.64
Measurand Mean 3.5
Measurand Min 0.6
Measurand Max 21.6
Measurand SD