Neuron specific enolase

Included in meta analysis


Wang S, Zhao M, Mu R, Zhang X, Yun K and Shang H, 2018, J Clin Lab Anal, 32(4), e22327 , Biological variation of serum neuron-specific enolase and carbohydrate antigen 724 tumor markers


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score B7

Item Details

Parameter Score
Matrix Serum
Measurand Neuron specific enolase
Unit ng / mL
Overall Analytical Principle Method Immunoassay; Not specified
Number of Subjects 20
Number of Subjects included in BV estimation 20
Ethinicity Caucasian
Age Mean / Median 29.0
Age Min 22.0
Age Max 49.0
Age SD
Number of Males 9
Number of Females 11
State of Well Being
Healthy (excl pregnant)
Study Duration Length 5
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 7:20
End Time: 8:10
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 10.1
Calculated Confidence Intervals of CVi Lower: 8.72, Upper: 11.98
Estimates of CVg 12.0
Calculated Confidence Intervals of CVg Lower: 8.66, Upper: 17.96
Analytical CV 1.9
Calculated Confidence Intervals of Analytical CV Lower: 1.67, Upper: 2.21
Measurand Mean 9.8
Measurand Min 6.2
Measurand Max 13.7
Measurand SD