Creatine Kinase

Included in meta analysis


Carobene A, Roraas T, Solvik UO, Sylte MS, Sandberg S, Guerra E, Marino I, Jonker N, Barla G, Barlett WA, Fernández-Calle P, Díaz-Garzón J, Tosato F, Plebani M, Coskun A, Serteser M, Unsal I and Ceriotti F, 2017, Clin Chem, 63, 1141-50 , Biological variation estimates obtained from 91 healthy study participants for 9 enzymes in serum


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand Creatine Kinase
Unit U / L
Overall Analytical Principle Method Enzymatic analysis - Not specified
Number of Subjects 84
Number of Subjects included in BV estimation 84
Ethinicity Caucasian
Age Mean / Median 37.0
Age Min 21.0
Age Max 69.0
Age SD
Number of Males 35
Number of Females 49
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:00
End Time: 10:00
Number of Samples 9
Average Number of Samples Used for BV Estimation 8.87
Average Number of Replicates 1.99
Estimates of CVi 14.5
Calculated Confidence Intervals of CVi Lower: 13.76, Upper: 15.33
Estimates of CVg 37.9
Calculated Confidence Intervals of CVg Lower: 32.84, Upper: 44.75
Analytical CV 0.9
Calculated Confidence Intervals of Analytical CV Lower: 0.85, Upper: 0.95
Measurand Mean 105.9
Measurand Min
Measurand Max
Measurand SD